Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is thought to play a role in the pathogenesis of cognitive disorders. However, the role of these neuroimaging findings in the context of normal cognitive aging is poorly understood. Identifying the etiologies of different types of lesions may help investigators differentiate between age-related and pathological […]

Amyloid hypothesis, the assumption that beta-amyloid toxicity is the primary cause of neuronal and synaptic loss, has been the mainstream research concept in Alzheimer’s disease for the past two decades. Currently, this model is quietly being replaced by a more holistic, “systemic disease” paradigm which, like the aging process, affects multiple body tissues and organs, […]

Sparse coding models of natural images and sounds have been able to predict several response properties of neurons in the visual and auditory systems. While the success of these models suggests that the structure they capture is universal across domains to some degree, it is not yet clear which aspects of this structure are universal […]