Increasing evidence supports a role for cerebrovasculature dysfunction in the aetiology of Alzheimer’s disease (AD). Blood vessels in the brain are composed of a collection of cells and acellular material that comprise the neurovascular unit (NVU). The NVU in the hippocampus and cortex receives innervation from cholinergic neurons that originate in the basal forebrain. Death […]

Although genetic factors contribute to neurodegenerative diseases such as dementia, the etiology of these disorders is complex and incompletely understood. Thus, a growing interest in different approaches including a developmental perspective to these pathologies is gaining momentum. Including environmental factors offers the possibility to enhance our understanding of the etiological factors resulting in the emergence […]

Abstract Humans regularly pursue activities characterized by dramatic success or failure outcomes where, critically, the chances of success depend on the time invested working toward it. How should people allocate time between such make‐or‐break challenges and safe alternatives, where rewards are more predictable (e.g., linear) functions of performance? We present a formal framework for studying […]