Amyloid-β (Aβ) deposition, neurofibrillary tangles induced by phosphorylation of tau protein and neuronal apoptosis are pathological hallmarks of Alzheimer’s disease (AD).The dementia rate in the alcoholic abusers were found to be higher than the control people. The present study explored potential roles of alcohol dehydrogenase 1B (ADH1B) in AD pathological process.The results showed that ADH1B […]

Many cognitive abilities decline with age even in the absence of detectable pathology. Recent evidence indicates that age-related neural dedifferentiation, operationalized in terms of neural selectivity, may contribute to this decline. We review here work exploring the relationship between neural dedifferentiation, cognition, and age. Compelling evidence for age effects on neural selectivity comes from both […]

Due to the limited field of view of the microscopes, acquisitions of macroscopic specimens require many parallel image stacks to cover the whole volume of interest. Overlapping regions are introduced among stacks in order to make it possible automatic alignment by means of a 3D stitching tool. Since state-of-the-art microscopes coupled with chemical clearing procedures […]