Episodic memory is the capacity to encode, store, and retrieve information of specific past events. Several studies have shown that decline in episodic memory accompanies aging, but most of these studies assessed memory performance through intentional learning. In this approach, the individuals deliberately acquire knowledge. Yet, another method to evaluate episodic memory performance – receiving […]

Postoperative cognitive decline (POCD) is a significant complication of surgery in elderly patients. Emerging researches showed that long noncoding RNA (lncRNA) may play a critical role in the pathogenesis of POCD. Here we aimed to identify potential key lncRNAs involved in the development of POCD. LncRNA and mRNA expression profiles in hippocampal tissues from POCD […]

It has been demonstrated that peroxisome proliferator-activated receptor γ (PPARγ) can regulate the transcription of its target gene, insulin-degrading enzyme (IDE) , and thus enhance the expression of the IDE protein. The protein can degrade β amyloid (Aβ), a core pathological product of Alzheimer’s disease (AD). PPARγ can also regulate the transcription of other target […]