The natural ecology of human language is face-to-face interaction comprising the exchange of a plethora of multimodal signals. Trying to understand the psycholinguistic processing of language in its natural niche raises new issues, first and foremost the binding of multiple, temporally offset signals under tight time constraints posed by a turn-taking system. This might be […]

Despite subjective cognitive decline (SCD), a preclinical stage of Alzheimer’s disease (AD), being widely studied in recent years, studies on centrality frequency in individuals with SCD are lacking. This study aimed to investigate the differences in centrality frequency between individuals with SCD and normal controls (NCs). Forty individuals with SCD and fifty-three well-matched NCs underwent […]

This work describes the conception, synthesis and in vitro and in vivo biological evaluation of novel Multi-Target Directed Ligands (MTDL) able to both activate 5-HT4 receptors, block 5-HT6 receptors and inhibit acetylcholinesterase activity (AChE), in order to exert a synergistic antiamnesic effect, potentially useful in Alzheimer’s disease (AD). Indeed, both activation of 5-HT4 and blockage […]