Cognitive neuroscience has traditionally focused on simple tasks, presented sparsely and using abstract stimuli. While this approach has yielded fundamental insights into functional specialisation in the brain, its ecological validity remains uncertain. Do these tasks capture how brains function ‘in the wild’, where stimuli are dynamic, multimodal, and crowded? Ecologically valid paradigms that approximate real […]

Subclinical cerebrovascular disease is frequently identified in neuroimaging studies and is thought to play a role in the pathogenesis of cognitive disorders. However, the role of these neuroimaging findings in the context of normal cognitive aging is poorly understood. Identifying the etiologies of different types of lesions may help investigators differentiate between age-related and pathological […]

Amyloid hypothesis, the assumption that beta-amyloid toxicity is the primary cause of neuronal and synaptic loss, has been the mainstream research concept in Alzheimer’s disease for the past two decades. Currently, this model is quietly being replaced by a more holistic, “systemic disease” paradigm which, like the aging process, affects multiple body tissues and organs, […]