What are the principles that govern whether neural representations move apart (differentiate) or together (integrate) as a function of learning? According to supervised learning models that are trained to predict outcomes in the world, integration should occur when two stimuli predict the same outcome. Numerous findings support this, but – paradoxically – some recent fMRI […]

The globus pallidus occupies a critical position in the indirect pathway of the basal ganglia motor control system. Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels play an important role in the modulation of neuronal excitability. In vivo extracellular single unit recording, behavioral test and immunohistochemistry were performed to explore the possible modulation of endogenous HCN channels in […]

Background: To study the extent that neuropsychiatric symptoms (NPS) influence the cognitive and functional decline in frontotemporal degeneration (FTD) and Alzheimer’s disease (AD). Methods: We assessed the progression of NPS and their influence on cognitive and functional progression in a group of FTD [n=36] and AD patients [n=47] at two different stages of the disease […]