As the prevalence of Alzheimer disease continues to rise unabated, new models have been put forth to improve our understanding of this devastating condition. Although individual models may have their merits, integrated models may prove more valuable. Indeed, the reliable failures of monotherapies for Alzheimer disease, and the ensuing surrender of major drug companies, suggests […]

Deep neural networks have led to state-of-the-art results in many medical imaging tasks including Alzheimer’s disease (AD) detection based on structural magnetic resonance imaging (MRI) data. However, the network decisions are often perceived as being highly non-transparent making it difficult to apply these algorithms in clinical routine. In this study, we propose using layer-wise relevance […]

Parkinson’s disease (PD) is the second most frequent neurodegenerative disease worldwide and the availability of early biomarkers and novel biotargets represents an urgent medical need. The main pathogenetic hallmark of PD is the specific loss of nigral dopaminergic neurons, in which mitochondrial dysfunction plays a crucial role. Mitochondrial proteases are central to the maintenance of […]