Although the mechanisms of Alzheimer’s disease are diverse and unclear, the past 20 years have witnessed the unprecedented development of the AD inflammation theory. As a key inflammatory receptor family, the C-C chemokine receptor family is a remarkable participant in the cause of Alzheimer’s disease; of this family, CCR5 is the most widely studied. CCR5 […]

Background and Purpose: Ambulatory blood pressure variability (ABPV), ambulatory blood pressure (ABP) and carotid intima-media thickness (IMT) are closely associated with white matter hyperintensities (WMH), few studies focused on establishing effective models based on ABP, ABPV and IMT to predict the WMH burden, we aimed to evaluate the value of predictive model based on metrics […]

The molecular basis of Parkinson’s (PD) disease is currently unknown. There is increasing evidence that fat metabolism is at the crossroad of key molecular pathways associated with the pathophysiology of PD. Fatty acid desaturases catalyze synthesis of saturated fatty acids from monounsaturated fatty acids thereby mediating several cellular mechanisms that are associated with diseases including […]