Soluble amyloid-β (Aβ) oligomers have been shown to induce oxidative stress, synaptic dysfunction and memory deficits which have been reported in Alzheimer’s disease (AD). Administration of γ-glutamylcysteine (GGC), a precursor to glutathione (GSH) can replenish depleted GSH levels, by circumventing the regulation of GSH biosynthesis and providing the limiting substrate. In this study, we examined […]
Published on August 9, 2019
BACKGROUND: Aging population undergoing surgery are at risk of postoperative cognitive dysfunction (POCD). Exploring effective and reliable early predictor of POCD is essential to identify high-risk patients and make prospective decisions. The purpose of this study was to examine whether preoperative insulin resistance, is an independent predictor of POCD. METHODS: A total of 124 aged […]
Published on August 9, 2019
Mild cognitive impairment (MCI) is a transitional state between the cognitive changes in normal aging and Alzheimer’s disease (AD), which induces abnormalities in specific brain regions. Previous studies showed that paired helical filaments Tau (PHF-Tau) protein is a potential pathogenic protein which may cause abnormal brain function and structure in MCI and AD patients. However, […]
Published on August 9, 2019
