Objectives: To explore the transfer effects of cognitive training on working memory among Chinese older adults with mild cognitive impairment (MCI). Methods: 62 MCI participants aged more than 60 years old were recruited by holding recruitment sessions at communities in China (33 for cognitive training, and 29 for mental leisure activities (MLA) control). Cognitive functions, […]

Alzheimer’s disease, and dementia, represents a common cause of disability and one of the most relevant challenges in the health world. In addition, this condition does not have, at moment, a pharmacological treatment that can stop the pathological progress. Mild cognitive impairment (MCI), defined as the borderline between normal aging and early dementia, represents a […]

Introduction. While the prevalence of neurodegenerative diseases associated with dementia such as Alzheimer’s disease (AD) increases, our knowledge on the underlying mechanisms, outcome predictors, or therapeutic targets is limited. In this work, we demonstrate how computational multi-scale brain modelling links phenomena of different scales and therefore identifies potential disease mechanisms leading the way to improved […]