Effective (fast, reliable, and accurate) information propagation through multiple brain regions underlies cognitive processes. However, it remains unclear how neural circuits support the propagation, particularly over a background of irregular firing and response latency. Here, we propose a temporal coding model for the cellular and network mechanisms of the cortical propagation through the anatomical-functional integration […]

Purpose: Predicting patient survival outcome is recognized as key importance to clinicians in oncology toward determining an ideal course of treatment and patient management. This study applies radiomics analysis on pre-operative multi-parametric MRI of patients with glioblastoma from multi-institution to identify a signature and a practical machine learning model for stratifying patients into groups based […]

Hallmarks of Alzheimer’s disease (AD) pathology include acetylcholine deficiency and plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact with amyloid beta (Aβ) to promote aggregation of insoluble amyloid beta plaques in brains of patients. Current therapeutic options available for AD patients, such as AChE inhibitors, provide only symptomatic relief. In this study, we […]