The accumulation of human islet amyloid polypeptide （hIAPP） in pancreatic islets under induction by a high-fat diet plays a critical role in the development of type-2 diabetes mellitus (T2DM). T2DM is a risk factor of late-onset Alzheimer’s disease (AD). Nevertheless, whether hIAPP in combination with hyperlipidemia may lead to AD-like pathological changes in the brain […]

Abstract Upon hearing a scalar adjective in a definite referring expression such as “the big…,” listeners typically make anticipatory eye movements to an item in a contrast set, such as a big glass in the context of a smaller glass. Recent studies have suggested that this rapid, contrastive interpretation of scalar adjectives is malleable and […]

Amyloid-β (Aβ) deposits and some proteins play some essential roles in AD pathogenesis. Amide proton transfer (APT) imaging as an indicator of tissue protein has shown promise for AD diseases. In this study, we chose 20 AD model rats as the experimental group and 20 sham-operated rats as the control group. They were firstly underwent […]