miR-146a is a microRNA (miRNA) involved in neuroinflammation and aging; alterations in its expression were described in Alzheimer’s disease (AD). However, most of the studies conducted so far on this miRNA included a limited number of participants and produced contradictory results. We compared miR-146a levels in plasma from 33 AD patients vs. 28 age-matched non-affected […]

Mechanisms underlying the selective vulnerability of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) over those in the ventral tegmental area (VTA) to degeneration in Parkinson’s disease (PD) remain poorly understood. DA neurons of SNpc and VTA are autonomous pacemakers but pacemaking in SNpc but not in VTA is accompanied by calcium influx […]

One of the most difficult and important decisions in power analysis involves specifying an effect size. Researchers frequently employ definitions of small, medium, and large that were proposed by Jacob Cohen. These definitions are problematic for two reasons. First, they are arbitrary, based on non-scientific criteria. Second, they are inconsistent, changing dramatically and illogically as […]