Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the isoforms of this protein in the adult brain of the two species differs. Tau 3R […]

By recording from microelectrodes in monkey prefrontal cortex (PFC), researchers have decoded the contents of conscious perception in cognitive areas (lateral prefrontal cortex) in conditions in which perceptions are not determined by the stimulus, binocular rivalry, and flash suppression [1–4]. As I noted in my recent Trends in Cognitive Sciences article [5], such results cannot […]

A central controversy in consciousness science concerns whether the neural correlates of consciousness (NCCs) exclusively reside posterior to the central sulcus or also include frontal regions [1–4]. In a recent Trends in Cognitive Sciences article, Block [5] contends that popular ‘no-report’ paradigms [6,7] cannot settle this dispute, since absence of report is consistent with extensive […]