Computer simulation of the human brain at an individual neuron resolution is an ultimate goal of computational neuroscience. The Japanese flagship supercomputer, K, provides unprecedented computational capability toward this goal. The cerebellum contains 80% of the neurons in the whole brain. Therefore, computer simulation of the human-scale cerebellum will be a challenge for modern supercomputers. […]

Background: An increasing lifespan and the resulting change in our expectations of later life stages are dependent on a good health state. This emphasizes the importance of the development of strategies to further strengthen healthy aging. One important aspect of good health in later life stages is sustained skilled motor function.Objective: Here, we tested the […]

Motivation plays a central role in human behavior and cognition but is not well captured by widely used artificial intelligence (AI) and computational modeling frameworks. This Opinion article addresses two central questions regarding the nature of motivation: what are the nature and dynamics of the internal goals that drive our motivational system and how can […]