Progressive accumulation of amyloid-β (Aβ) plaques in the brain is a characteristic pathological change in Alzheimer’s disease (AD). We previously found the expression of lipoprotein lipase (LPL) was increased in SH-SY5Y cells exposed to low-dose Aβ and decreased in cells with high-dose Aβ exposure, but the molecular mechanism is still unclear. Based on previous studies, […]

Cognitive scientists have ramped up online testing in response to the coronavirus pandemic. Although research conducted online solves the problem of data collection, a lack of internet access among low-income and minority communities may reduce the diversity of study samples and, thus, impact the generalizability of scientific findings. Read Full Article (External Site) Dr. David […]

The exponential time differencing (ETD) method allows using a large time step to efficiently evolve stiff systems such as Hodgkin-Huxley (HH) neural networks. For pulse-coupled HH networks, the synaptic spike times cannot be predetermined and are convoluted with neuron’s trajectory itself. This presents a challenging issue for the design of an efficient numerical simulation algorithm. […]