Type 2 diabetes mellitus (T2DM) increases the risk of Alzheimer’s disease (AD)-like dementia and pathology. Endoplasmic reticulum stress (ERS) plays a key role in the development of cognitive impairment in T2DM. Zonisamide (ZNS) was found to suppress ERS-induced neuronal cell damage in the experimental models of Parkinson’s disease (PD). However, the protective effect of Zonisamide […]
Published on July 9, 2020
Physiologically detailed models of neural networks are an important tool for studying how biophysical mechanisms impact neural information processing. An important, fundamental step in constructing such a model is determining where neurons are placed and how they connect to each other, based on known anatomical properties and constraints given by experimental data. Here we present […]
Published on July 8, 2020
The storage of temporally precise spike patterns can be realized by a single neuron. A spiking neural network (SNN) model is utilized to demonstrate the ability to precisely recall a spike pattern after presenting a single input. We show by using a simulation study that the temporal properties of input patterns can be transformed into […]
Published on July 8, 2020
