The view that conceptual knowledge is explored through mechanisms originally deputed to navigate the physical space is theoretically fascinating and supported by an increasing body of multidisciplinary data. In their article, Bottini and Doeller proposed that spatial organizational principles of the hippocampal–parietal network can be favorably exploited to handle mental representations [1]. The priority assigned […]

BackgroundNeuromodulation therapies, such as deep brain stimulation (DBS), spinal cord stimulation (SCS), responsive neurostimulation (RNS), transcranial magnetic stimulation (TMS), transcranial direct stimulation (tDCS), and vagus nerve stimulation (VNS) are used to treat neurological and psychiatric conditions for patients who have failed to benefit from other treatment approaches. Although generally effective, seemingly similar cases often have […]

BackgroundGait deficits are associated with brain atrophy and white matter hyperintensities (WMH) – both markers of underlying cerebral small vessel disease (SVD). Given reduced subcortical cerebral blood flow (CBF) is prevalent in SVD, we tested the hypothesis that regional CBF is positively associated with gait performance among older adults.MethodsThirty-two older adults (55–80 years) with at […]