Neuroimaging and behavioral evidence of sex-specific effects of oxytocin on human sociality

Published on July 25, 2024

Although the social role of oxytocin came to light due to sex-specific interactions such as mother–offspring bonding, current understanding of sex differences in the effects of oxytocin on human sociality is limited because of the predominance of all-male samples. With the increasing inclusion of females in intranasal oxytocin research, it is now possible to explore such patterns. Neuroimaging studies reveal relatively consistent sex-differential effects of oxytocin on the activation of brain regions associated with processing social stimuli – particularly the amygdala. Findings from behavioral research are varied but suggest that oxytocin more often facilitates social cognition and positive social interactions in males, with context-dependent effects in each sex. We discuss potential biological and psychological mechanisms underlying the reported sex differences, and conclude with considerations for future research and clinical applications of oxytocin.

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