Month: January 2024

Study Identifies Early-Onset Dementia Risk Factors

Researchers from the University of Exeter in England and Maastricht University in the Netherlands have identified 15 key risk factors that could lead to dementia before the age of 65. Dementia “is a general term for conditions that cause loss of memory severe enough that… Read Full Article (External Site) Dr. David LowemannDr. David Lowemann, […]

Published on January 12, 2024

From theory to practice: translating the concept of cognitive resilience to novel therapeutic targets that maintain cognition in aging adults

While the concept of cognitive resilience is well-established it has not been defined in a way that can be measured. This has been an impediment to studying its underlying biology and to developing instruments for its clinical assessment. This perspective highlights recent work that has quantified the expression of cortical proteins associated with cognitive resilience, […]

Published on January 12, 2024

Activated microglia release β−galactosidase that promotes inflammatory neurodegeneration

Beta (β)-galactosidase is a lysosomal enzyme that removes terminal galactose residues from glycolipids and glycoproteins. It is upregulated in, and used as a marker for, senescent cells. Microglia are brain macrophages implicated in neurodegeneration, and can upregulate β-galactosidase when senescent. We find that inflammatory activation of microglia induced by lipopolysaccharide results in translocation of β-galactosidase […]

Published on January 12, 2024