Month: November 2023

Age-related differences in risk factors, clinical characteristics, and outcomes for intracerebral hemorrhage

Background and purposeIntracerebral hemorrhage (ICH) is a severe form of stroke that remains understudied in the young adults. We aimed to investigate the clinical presentation, and risk factors associated with ICH in this age group and compare them to older patients.MethodsOur study included ICH patients admitted between March 2016 and December 2021 in the First […]

Published on November 3, 2023

Low bone mineral density is associated with gray matter volume decrease in UK Biobank

ObjectivesPrevious research has found an association of low bone mineral density (BMD) and regional gray matter (GM) volume loss in Alzheimer’s disease (AD). We were interested whether BMD is associated with GM volume decrease in brains of a healthy elderly population from the UK Biobank.Materials and methodsT1-weighted images from 5,518 women (MAge = 70.20, SD = 3.54; age range: […]

Published on November 3, 2023

CCL5 promotes LFA-1 expression in Th17 cells and induces LCK and ZAP70 activation in a mouse model of Parkinson’s disease

BackgroundParkinson’s disease (PD), which is associated to autoimmune disorders, is characterized by the pathological deposition of alpha-synuclein (α-Syn) and loss of dopaminergic (DA) neurons. Th17 cells are thought to be responsible for the direct loss of DA neurons. C-C chemokine ligand 5 (CCL5) specifically induces Th17 cell infiltration into the SN. However, the specific effect […]

Published on November 3, 2023