Month: November 2023

Corrigendum: Learning the heterogeneous representation of brain’s structure from serial SEM images using a masked autoencoder

Read Full Article (External Site) Dr. David LowemannDr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated […]

Published on November 27, 2023

Quantitative iron–neuromelanin MRI associates with motor severity in Parkinson’s disease and matches radiological disease classification

BackgroundNeuromelanin- and iron-sensitive MRI studies in Parkinson’s disease (PD) are limited by small sample sizes and lack detailed clinical correlation. In a large case–control PD cohort, we evaluated the diagnostic accuracy of quantitative iron–neuromelanin MRI parameters from the substantia nigra (SN), their radiological utility, and clinical association.MethodsPD patients and age-matched controls were prospectively recruited for […]

Published on November 27, 2023

Exploring epigenetic drift and rare epivariations in amyotrophic lateral sclerosis by epigenome-wide association study

During the last decades, our knowledge about the genetic architecture of sporadic amyotrophic lateral sclerosis (sALS) has significantly increased. However, besides the recognized genetic risk factors, also the environment is supposed to have a role in disease pathogenesis. Epigenetic modifications reflect the results of the interaction between environmental factors and genes and may play a […]

Published on November 27, 2023