The Power of Muscles: Predicting Working Memory in Older Adults

Published on October 9, 2023

Imagine your brain as a team of workers, with each member responsible for a different task. In this study, we wanted to see if the strength of your muscles could predict the performance of one particular worker – your working memory (WM). WM is like the brain’s post-it note, allowing you to hold and manipulate information in your mind while completing a task. Previous research has focused on the link between muscle strength and overall cognitive function, but little is known about its connection to more advanced cognitive abilities, such as WM. To unravel this mystery, we gathered a group of older adults and tested their muscle strength, WM performance, and the activity of their prefrontal cortex using a fancy brain imaging technique called functional near-infrared spectroscopy (fNIRS). Excitingly, we discovered that participants with stronger muscles had better WM performance! This suggests that having strong muscles might give your working memory an extra boost. We also found that certain regions of the prefrontal cortex showed different levels of oxygenation depending on muscle strength. However, these brain changes did not fully explain the relationship between muscle strength and WM performance. So there could be other fascinating factors at play! If you’re curious to learn more about how your muscles can impact your brain, feel free to delve into the detailed research.

ObjectivePrevious research has primarily focused on the association between muscle strength and global cognitive function in older adults, while the connection between muscle strength and advanced cognitive function such as inhibition and working memory (WM) remains unclear. This study aimed to investigate the relationship among muscle strength, WM, and task-related cortex hemodynamics.MethodsWe recruited eighty-one older adults. Muscle strength was measured using a grip and lower limb strength protocol. We measured the WM performance by using reaction time (RT) and accuracy (ACC) in the N-back task and the cortical hemodynamics of the prefrontal cortex (PFC) by functional near-infrared spectroscopy (fNIRS).ResultsWe found positive correlations between grip strength (p < 0.05), 30-s sit-up (p < 0.05) and ACC, negative correlation between grip strength (p < 0.05) and RT. Furthermore, we observed positive correlations between grip strength and the level of oxygenated hemoglobin (HbO2) in dorsolateral prefrontal cortex, frontopolar area, ventrolateral prefrontal cortex (p < 0.05), and negative correlations between grip strength and the level of deoxygenated hemoglobin (Hb) in left dorsolateral prefrontal cortex, frontopolar area, left ventrolateral prefrontal cortex (p < 0.05). Additionally, we noticed positive correlations between RT and the level of Hb in left dorsolateral prefrontal cortex, right frontopolar area (p < 0.05), and negative correlations between RT and the level of HbO2 in left dorsolateral prefrontal cortex, frontopolar area (p < 0.05). However, the cortical hemodynamics did not mediate the relationship between muscle strength and WM performance (RT, ACC).ConclusionThe grip strength of older adults predicted WM in the cross-section study. The level of hemodynamics in PFC can serve as a predictor of WM.

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