Alzheimer’s Mouse Brain Softens in Hippocampus

Published on August 28, 2023

A recent study has found that the hippocampus of a mouse model of Alzheimer’s disease experiences region-specific tissue softening along with increased astrogliosis. This is similar to how a water balloon becomes softer and more fragile in certain areas when filled to capacity. Astrogliosis, which is the increase in the number and size of astrocytes in response to injury or disease, is like a team of repair workers that rush to fix a leaky pipe. The researchers speculate that the tissue softening may be due to changes in the extracellular matrix, which is the structural network that supports the cells in the brain. Further investigation is needed to fully understand this phenomenon. If we can unravel the mechanisms behind tissue softening, it could potentially lead to new treatments for Alzheimer’s disease. To learn more about this fascinating research, check out the full article!

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