Aging brains impact tool use performance, fMRI shows

Published on August 22, 2023

Like a well-loved puzzle piece slowly losing its shape, the aging brain undergoes changes that affect our ability to use tools effectively throughout our lives. However, the true extent of these changes and how they contribute to impaired tool use in apraxia patients has remained a mystery. In this groundbreaking fMRI study, researchers set out to unravel the neural correlates of planning and executing complex object manipulation tasks in both younger and older adults. They found that while the left-lateralized network responsible for tool use remains resilient to age-related functional changes, older participants show differences in their strategic approach to the task. This highlights the importance of investing more effort into the planning phase for successful tool use as we grow older. By better understanding the impact of aging on tool use performance, we can develop targeted interventions and support systems to help individuals maintain their independence and quality of life.

IntroductionHealthy aging affects several domains of cognitive and motor performance and is further associated with multiple structural and functional neural reorganization patterns. However, gap of knowledge exists, referring to the impact of these age-related alterations on the neural basis of tool use–an important, complex action involved in everyday life throughout the entire lifespan. The current fMRI study aims to investigate age-related changes of neural correlates involved in planning and executing a complex object manipulation task, further providing a better understanding of impaired tool use performance in apraxia patients.MethodsA balanced number of sixteen older and younger healthy adults repeatedly manipulated everyday tools in an event-related Go-No-Go fMRI paradigm.ResultsOur data indicates that the left-lateralized network, including widely distributed frontal, temporal, parietal and occipital regions, involved in tool use performance is not subjected to age-related functional reorganization processes. However, age-related changes regarding the applied strategical procedure can be detected, indicating stronger investment into the planning, preparatory phase of such an action in older participants.

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