The Brain’s GPS: Navigating Wrist Movement in Intrinsic vs. Extrinsic Coordinates

Published on July 10, 2023

Imagine your brain as a complex GPS, guiding your wrist movement in different coordinate systems. This study used brain imaging and connectivity analysis to compare how the brain processes intrinsic and extrinsic motor coordinates during wrist movements. Researchers found that the brain utilizes distinct networks for each coordinate system. The inferior parietal lobule receives extrinsic information from the rostral lingual gyrus and transmits intrinsic information to the Handknob, while extrinsic information is sent directly to the Handknob from the rostral lingual gyrus. Additionally, a behavioral experiment revealed a delay in muscle activity for intrinsic coordinate-directed wrist movements compared to extrinsic ones. These findings suggest that when our movements are externally directed, the brain bypasses the use of intrinsic coordinate information to reach the primary motor area.

This study explores brain-network differences between the intrinsic and extrinsic motor coordinate frames. A connectivity model showing the coordinate frames difference was obtained using brain fMRI data of right wrist isometric flexions and extensions movements, performed in two forearm postures. The connectivity model was calculated by machine-learning-based neural representation and effective functional connectivity using psychophysiological interaction and dynamic causal modeling analyses. The model indicated the network difference wherein the inferior parietal lobule receives extrinsic information from the rostral lingual gyrus through the superior parietal lobule and transmits intrinsic information to the Handknob, whereas extrinsic information is transmitted to the Handknob directly from the rostral lingual gyrus. A behavioral experiment provided further evidence on the difference between motor coordinate frames showing onset timing delay of muscle activity of intrinsic coordinate-directed wrist movement compared to extrinsic one. These results suggest that, if the movement is externally directed, intrinsic coordinate system information is bypassed to reach the primary motor area.

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