Imagine deep brain stimulation as a mystical ballet, where the dancers (electrodes) perform different moves and rhythms to influence the entire performance (neuronal firing and network effects). Conventional high-frequency stimulation is like a steady waltz, but emerging alternative patterns offer exciting possibilities. These patterns include theta-frequencies, variable frequencies, coordinated reset stimulation, and more. Scientists are currently exploring these new dance routines to understand how they can benefit patients with neurological and neuropsychiatric disorders. By adjusting parameters such as pulse width, interstimulus interval, frequency, and amplitude, researchers can create unique combinations of stimulation patterns tailored to individual needs. This opens up a world of potential clinical applications for deep brain stimulation. Want to dive deeper into this mesmerizing dance between electrodes and neural networks? Check out the underlying research!
Deep brain stimulation (DBS) is a widely used clinical therapy that modulates neuronal firing in subcortical structures, eliciting downstream network effects. Its effectiveness is determined by electrode geometry and location as well as adjustable stimulation parameters including pulse width, interstimulus interval, frequency, and amplitude. These parameters are often determined empirically during clinical or intraoperative programming and can be altered to an almost unlimited number of combinations. Conventional high-frequency stimulation uses a continuous high-frequency square-wave pulse (typically 130–160 Hz), but other stimulation patterns may prove efficacious, such as continuous or bursting theta-frequencies, variable frequencies, and coordinated reset stimulation. Here we summarize the current landscape and potential clinical applications for novel stimulation patterns.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.