Boosting Alzheimer’s Disease Detection Using Memory Load

Published on June 2, 2023

Imagine you’re at a bustling farmer’s market, trying to detect the ripest fruits in a sea of vibrant colors. When you’re not carrying much, it’s easier to notice the subtle variations in texture and smell that indicate the perfect produce. The same concept applies to detecting Alzheimer’s disease through speech-based tests. Researchers conducted a study to determine if increasing the memory load during speech tasks could enhance the accuracy of detection. They collected speech samples from Alzheimer’s patients and healthy older adults, using tasks with different memory loads. Through their analysis, they discovered that speech characteristics associated with Alzheimer’s, such as pitch, loudness, and speech rate, were more pronounced in high-memory-load tasks. In fact, the high-memory-load task performed exceptionally well in classifying Alzheimer’s disease with an impressive accuracy of 81.4% and predicting MMSE scores with a mean absolute error of 4.62. This suggests that incorporating memory-intensive tasks into diagnostic models can significantly improve their effectiveness, making them a valuable tool for early detection of Alzheimer’s disease. To delve deeper into this fascinating research, check out the full article!

IntroductionThe study aims to test whether an increase in memory load could improve the efficacy in detection of Alzheimer’s disease and prediction of the Mini-Mental State Examination (MMSE) score.MethodsSpeech from 45 mild-to-moderate Alzheimer’s disease patients and 44 healthy older adults were collected using three speech tasks with varying memory loads. We investigated and compared speech characteristics of Alzheimer’s disease across speech tasks to examine the effect of memory load on speech characteristics. Finally, we built Alzheimer’s disease classification models and MMSE prediction models to assess the diagnostic value of speech tasks.ResultsThe speech characteristics of Alzheimer’s disease in pitch, loudness, and speech rate were observed and the high-memory-load task intensified such characteristics. The high-memory-load task outperformed in AD classification with an accuracy of 81.4% and MMSE prediction with a mean absolute error of 4.62.DiscussionThe high-memory-load recall task is an effective method for speech-based Alzheimer’s disease detection.

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