Vibrotactile Stimulation: A Promising Strategy for Neurodegeneration

Published on May 18, 2023

Just like the flickering light therapy we previously discussed, whole-body vibrotactile stimulation at a specific frequency of 40 Hz has shown promising results in mitigating pathology and improving motor function in mouse models of neurodegeneration. In this study, researchers explored the effects of this type of stimulation on the primary somatosensory cortex (SSp) and primary motor cortex (MOp). Daily exposure to 40 Hz vibrotactile stimulation led to increased neural activity in these areas and decreased brain pathology. Moreover, mice with neurodegenerative conditions showed improved motor performance after weeks of daily stimulation. It’s incredible how different sensory modalities can have such significant impacts on the brain and body! If you want to dive deeper into this exciting research, check out the full article below!

The risk for neurodegenerative diseases increases with aging, with various pathological conditions and functional deficits accompanying these diseases. We have previously demonstrated that non-invasive visual stimulation using 40 Hz light flicker ameliorated pathology and modified cognitive function in mouse models of neurodegeneration, but whether 40 Hz stimulation using another sensory modality can impact neurodegeneration and motor function has not been studied. Here, we show that whole-body vibrotactile stimulation at 40 Hz leads to increased neural activity in the primary somatosensory cortex (SSp) and primary motor cortex (MOp). In two different mouse models of neurodegeneration, Tau P301S and CK-p25 mice, daily exposure to 40 Hz vibrotactile stimulation across multiple weeks also led to decreased brain pathology in SSp and MOp. Furthermore, both Tau P301S and CK-p25 mice showed improved motor performance after multiple weeks of daily 40 Hz vibrotactile stimulation. Vibrotactile stimulation at 40 Hz may thus be considered as a promising therapeutic strategy for neurodegenerative diseases with motor deficits.

Read Full Article (External Site)

Leave a Reply

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes:

<a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>