The importance of studying neural development for understanding brain function

Published on May 31, 2023

Just like a puzzle, understanding the function of neural circuits requires knowing how they were put together. This is the main idea behind developmental systems neuroscience. Instead of just looking at the end result, we need to study how these circuits develop and change over time. It’s like watching a seed grow into a beautiful flower, and seeing how each stage of growth influences its overall appearance. In the same way, the interactions between different neural assemblies play a crucial role in shaping their function. This concept is called ‘enbrainment’, which means that the functional role of a neural assembly is determined by its connections with other assemblies as it develops. Researchers have been advocating for this perspective in cognitive development for decades, emphasizing the importance of considering developmental trajectories rather than just final outcomes.

To understand the functional role of neural circuits we must understand the developmental history of those circuits. This is the guiding principle underpinning developmental systems neuroscience (see Glossary). Put simply, we must study trajectories of developmental change [1,2] rather than end-state outcomes alone, because the functional role of any neural assembly is shaped by its interactions with other assemblies, across development. This phenomenon is sometimes termed ‘enbrainment’ [3,4]. Over the past 30 years, it has been argued that this perspective should be central to how we understand cognitive development [3–9].

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