Early experiences can have broad and lasting effects on later health and thriving [1–3]. These effects are clearly not deterministic; many people are resilient, but early adversity increases the chance of later difficulties. The practical importance of these findings is clear. But they pose a crucial question: how and why does this happen? One possibility is that there is a cascade of causes: childhood adversity tends to lower school performance, which tends to lower incomes, which tends to lower health, and so on.