Domestication (see Glossary) represents one of the single largest biological shifts of life on Earth, and the biomass of livestock now outweighs that of wild mammals by more than two orders of magnitude [1]. This shift was part of the biocultural feedback loop that brought humans to our remarkable present-day position in the animal kingdom [2]. Furthermore, substantial scientific debate has recently focused on whether a domestication syndrome links phenotypes across species ([3] versus [4]) and whether humans are self-domesticated ([5,6] versus [7,8]).