Imagine a car that starts to have engine trouble before showing any other signs of wear and tear. In a similar fashion, scientists have observed that motor dysfunction, such as problems with movement and balance, often appear before other symptoms in patients with Alzheimer’s Disease (AD). However, the underlying mechanisms behind this phenomenon have remained […]
Imagine a conductor leading an orchestra, ensuring that every musician plays their part in harmony. The TAR DNA binding protein 43 kDa (TDP-43) plays a similar role in our cells, orchestrating essential functions. However, when TDP-43 goes awry, it can set off a chain reaction of dysfunction that may contribute to neurodegenerative diseases like ALS and […]
Imagine a raging river, powerful and unforgiving. But what if you had two mighty warriors working together to tame it? That’s the story of PCSK9 inhibition and statin therapy teaming up to battle intracranial atherosclerotic stenosis (ICAS), a common cause of stroke worldwide. In this study, researchers investigated the effects of combining PCSK9 inhibition with […]
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