Aging brains respond differently to rewards and punishments

Published on March 6, 2023

As we age, our brains change how they respond to rewards and punishments. A recent fMRI study examined the brain activity of older adults while they made decisions based on rewards and risks. The results showed that older adults were able to improve their decision-making when rewards were involved, but struggled to avoid making bad choices when faced with punishments. The study found that certain regions of the brain, such as the middle frontal cortex and superior medial frontal cortex, played a role in this age-related decline in decision-making. Interestingly, the older adults were more sensitive to high punishment frequencies compared to younger adults. These findings offer insight into how aging impacts our risk-taking behaviors and highlight the importance of understanding how our brains change over time. To dive deeper into this fascinating research, check out the full article!

IntroductionAging is often accompanied by significant cognitive decline and altered decision making. Previous studies have found that older adults have difficulty in processing reward/risk information, leading to suboptimal decision strategy. However, it is still under investigated about the neural substrates of risky decision-making under ambiguity in aging.MethodsUsing the Iowa Gambling Task, the current study investigated inter-individual differences of risk-taking behaviors in healthy older adults with task-related functional magnetic resonance imaging.ResultsIt was found that participants were able to improve their decisions in advantageous decks, but failed to avoid disadvantageous decks during task performance. The task-related activations within multiple brain regions were observed significantly different across the four decks, and showed negative correlations with age in disadvantageous decks but not in advantageous decks. Consistently, age-related whole brain analyses confirmed the negative age-effect on brain activations in disadvantageous decks, especially in high punishment frequency. In addition, the relationship between age and task performance in high punishment frequency was mediated by activation in the frontal subregions such as the middle frontal cortex and superior medial frontal cortex.DiscussionOur findings shed light on the neural substrates of altered risk-taking behaviors in aging, suggesting a greater sensitivity to high punishment frequency in older adults.

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