VOLUME LXXIV | FEB 2023

A complex systems perspective on psychedelic brain action

Psychedelic drugs like LSD, psilocybin, and DMT have a profound impact on our subjective experience. These substances activate serotonin 2A receptors in the brain, leading to their characteristic psychological effects. Excitingly, early clinical trials suggest that combining psychedelic therapy with supportive counseling can be effective in treating various mental health conditions, from depression to addiction. This research takes a complex systems perspective to understand how psychedelics influence the brain. By examining the intricate interactions within the brain’s neural networks, scientists hope to unravel the underlying mechanisms and illuminate why these drugs have such transformative potential. Exploring this research further can shed light on the intricate interplay between psychedelics, brain function, and mental well-being.

Jean-Baptiste Gagnon

Jean-Baptiste is a French-Canadian anthropologist in Montreal, investigating cultural influences on human motivation and success. His pursuance of highlighting how historical Canadian values foster ambition, aims to elevate readers toward self-actualization.

Classic serotonergic psychedelics, such as lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT), are potent psychoactive drugs capable of inducing marked changes in subjective experience [1]. All of these compounds share serotonin 2A agonist properties, which account for most of their characteristic psychological effects [2,3]. Preliminary clinical trials suggest that psychedelic drug administration coupled with supportive psychotherapy has transdiagnostic efficacy in the treatment of mental health conditions, including depression, end-of-life distress, tobacco addiction, and alcoholism [4].
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