Imagine a revolutionary treatment that could improve the lives of those suffering from moderate-to-severe Alzheimer’s disease. That’s where repetitive transcranial magnetic stimulation (rTMS) comes in. In a recent study, researchers conducted a randomized, sham-controlled clinical trial involving 35 AD patients. They applied high-frequency stimulation to the left dorsolateral prefrontal cortex over a period of three months. The results were astounding! Participants who received rTMS showed significant improvements in cognitive performance, reduced psychiatric symptoms, and an overall positive global impression of change. But the excitement doesn’t stop there! Researchers also found potential neuroimaging markers that could predict individual treatment outcomes before administering rTMS. This opens up a whole new realm of possibilities for tailoring treatment to each patient’s needs. Don’t miss out on this groundbreaking research! Dive deeper into the fascinating world of rTMS treatment for moderate and severe AD patients by exploring the full article.
The repetitive transcranial magnetic stimulation (rTMS) shows great potential in the treatment of Alzheimer’s disease (AD). However, its treatment efficacy for AD patients in moderate to severe stage is relatively evaluated. Here, we proposed a randomized, sham-controlled, clinical trial of rTMS among 35 moderate-to-severe AD patients. A high frequency (10 Hz) stimulation of the left dorsal lateral prefrontal cortex (DLPFC), 60-session long treatment lasting for 3 months procedure was adopted in the trial. Each participant completed a battery of neuropsychological tests at baseline and post-treatment for evaluation of the rTMS therapeutic effect. Twelve of them completed baseline resting-state functional magnetic resonance imaging (fMRI) for exploration of the underlying neural contribution to individual difference in treatment outcomes. The result showed that the rTMS treatment significantly improved cognitive performance on the severe impairment battery (SIB), reduced psychiatric symptoms on the neuropsychiatric inventory (NPI), and improved the clinician’s global impression of change (CIBIC-Plus). Furthermore, the result preliminarily proposed resting-state multivariate functional connectivity in the (para) hippocampal region as well as two clusters in the frontal and occipital cortices as a pre-treatment neuroimaging marker for predicting individual differences in treatment outcomes. The finding could brought some enlightenment and reference for the rTMS treatment of moderate and severe AD patients.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.