Uric Acid and Cognitive Function: A Surprising Connection in Older Adults

Published on December 8, 2022

Imagine uric acid as a superhero, swooping in to save your cognition! This study explores the relationship between serum uric acid (SUA) levels and cognitive function in older American adults. The researchers used data from a large population-based analysis to reveal a positive correlation between SUA and cognitive performance. It’s like finding out that eating strawberries actually boosts your brainpower! Although previous studies have given conflicting results, this study provides evidence supporting the idea that having slightly elevated SUA within the normal range can actually benefit cognitive function. It’s as if a little extra uric acid is like having a secret power-up for your brain. However, there’s still more to uncover about the precise dose and time relationship. So, stay tuned for future research on this captivating connection and consider exploring the full article for all the intriguing details!

BackgroundThe many studies revealing a connection between serum uric acid (SUA) and dementia have reported conflicting results. This study sought to investigate the relations between SUA and cognitive function in older adults.Materials and methodsThe sample was 2,767 American adults aged ≥60 years from the National Health and Nutrition Examination Survey 2011–2014. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer’s Disease test, animal fluency test, digit symbol substitution test, and composite z-score. Multivariate linear regression analyses were conducted to estimate the association between SUA and cognitive function.ResultsSUA level and cognitive function were significantly, positively correlated. Age significantly correlated with the association between SUA and cognitive function.ConclusionThese findings support a connection between SUA and cognition, showing a positive link between SUA and cognitive scores among older American adults. We contend that a slight rise in uric acid within the normal range is advantageous for enhanced cognition. To confirm the precise dose-time-response relation, more tests will be needed.

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