Understanding Alzheimer’s disease is like navigating a dense jungle filled with various plants and animals. Apart from the well-known features of the disease, such as amyloid pathology and tau-related neurodegeneration, there are many other molecular alterations and pathway dysregulations that remain poorly understood. These complex interactions and variations between individuals make diagnosis, treatment, and drug design challenging. Thankfully, scientists have developed high-throughput ‘omics’ approaches, which are like multifunctional tools capable of exploring the intricate web of changes happening within the disease. By integrating data from different omics methods, these approaches provide a more comprehensive understanding of the disease’s molecular signatures and interactions at various biological levels. This allows researchers to delve deeper into the underlying mechanisms of Alzheimer’s. In this review, we delve into the different multi-omics tools and approaches available and how they have been used in AD research so far. We explore how these approaches can uncover molecular alterations related to core features of AD and their interplay with other pathological alterations. Furthermore, we investigate whether these discovered changes have clinical relevance, impacting cognition, neuropsychiatric symptoms, and disease progression. Lastly, we highlight the potential for multi-omics approaches to identify novel biomarkers for diagnosis and personalized intervention strategies in Alzheimer’s. Grab your binoculars and venture into the exciting world of multi-omics research to unravel the mysteries of Alzheimer’s!
The Institute for the Future of Human Potential
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