Just like shadows cast by nearby objects, the brain has a penumbra of memory that can save mundane recollections from fading away. Scientists have delved into this phenomenon, connecting neurobiological mechanisms observed in rodents to recent behavioral findings in humans. By investigating the synaptic-tagging-and-capture hypothesis, which relies on the presence of synaptic tags and plasticity-related proteins (PRPs), researchers offer insights into how a weak memory trace can become enduring when a significant event occurs within a critical time window. This new exploration shines light on memory processing, particularly in older individuals or those with neurological conditions. Further studies in this area may help elucidate therapeutic strategies for preserving memory function in aging populations or individuals with memory-related disorders.
We thank Dunsmoor et al. [1] for their timely and comprehensive examination of how salient events, including novelty and emotion, can save mundane memories from oblivion when encountered in close temporal proximity – an effect sometimes referred to as ‘memory’s penumbra’. We specifically applaud their efforts in linking neurobiological mechanisms as identified in rodents to emerging behavioral findings in humans, while explaining these in light of existing memory models. They address the synaptic-tagging-and-capture hypothesis – for which two conditions are indispensable: (i) local setting of synaptic tags generated by appropriate synaptic activity; and (ii) availability of plasticity-related proteins (PRPs) that are synthesized as a result of the activation of neuromodulatory systems in a time-dependent manner [2] – to explain how on a neuronal level an initially weak memory trace becomes stable when a salient event is experienced during a critical time window around it.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.