Just like a skilled multitasker, TP53-induced glycolysis and apoptosis regulator (TIGAR) takes on different roles in the nervous system. It acts as a traffic controller for glucose metabolism, ensuring the synthesis of ribose for DNA repair and cell growth while maintaining a balanced cellular environment. TIGAR also wears many hats, working to reduce oxidative stress, inflammation, and apoptosis, all while keeping autophagy in check. Scientists have been investigating the connection between TIGAR and various neurological diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, seizures, and brain tumors. Understanding the intricate involvement of TIGAR in these disorders could pave the way for novel therapeutic targets and strategies to combat these debilitating conditions. For a deep dive into the research on TIGAR’s impact on the nervous system and its potential implications for treating neurological diseases, check out the full article!
TP53-induced glycolysis and apoptosis regulator (TIGAR) mainly regulates pentose phosphate pathway by inhibiting glycolysis, so as to synthesize ribose required by DNA, promote DNA damage repair and cell proliferation, maintain cell homeostasis and avoid body injury. Its physiological functions include anti-oxidative stress, reducing inflammation, maintaining mitochondrial function, inhibiting apoptosis, reducing autophagy etc. This paper reviews the research of TIGAR in neurological diseases, including stroke, Parkinson’s disease (PD), Alzheimer’s disease (AD), seizures and brain tumors, aiming to provide reference for the development of new therapeutic targets.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.