Imagine a bustling city street, where people are going about their day, each with a specific job to do. In this city, one particular group called microglia play a crucial role in maintaining peace and order. Just like the immune system keeps our bodies healthy, microglia are the guardians of the brain, protecting it from harm. However, in Parkinson’s disease, there is a disturbance in this delicate dance. A protein called α-synuclein starts piling up in the brain, disrupting the balance and triggering microglia into action. Through a process called autophagy, these vigilant cells try to eliminate the unwanted protein and restore harmony. This review delves into the intricate pathways of microglial autophagy and explores its role in Parkinson’s disease pathology. By understanding how autophagy affects microglia, scientists hope to uncover potential therapeutic targets for treating PD and restoring balance to the city of the brain.
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Studies have shown that abnormal accumulation of α-synuclein (α-Syn) in the substantia nigra is a specific pathological characteristic of PD. Abnormal accumulation of α-Syn in PD induces the activation of microglia. Microglia, which are immune cells in the central nervous system, are involved in the function and regulation of inflammation in PD by autophagy. The role of microglial autophagy in the pathophysiology of PD has become a hot-pot issue. This review outlines the pathways of microglial autophagy, and explores the key factor of microglial autophagy in the mechanism of PD and the possibility of microglial autophagy as a potential therapeutic target for PD.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.