Unraveling the Intriguing Connection: Electroacupuncture and NLRP3 Inflammasome

Published on October 19, 2022

Just like a detective uncovering clues to solve a complex mystery, scientists are unraveling the fascinating link between electroacupuncture and the NLR family pyrin domain containing 3 (NLRP3) inflammasome. Electroacupuncture, a popular alternative medicine treatment, has shown promising results in various conditions, but its exact mechanism has remained elusive. The NLRP3 inflammasome, a key player in immune system diseases, has piqued researchers’ interest as a potential contributor to the effects of electroacupuncture. By analyzing existing clinical trials and controlled studies, scientists have begun connecting the dots and shedding light on how electroacupuncture influences the NLRP3 inflammasome in different diseases. This groundbreaking research not only highlights the therapeutic potential of electroacupuncture but also provides insights into optimizing treatment protocols and improving the evidence base. Dive into this captivating field of study to gain a deeper understanding of how ancient practices like electroacupuncture intersect with modern biomedical science!

Electroacupuncture, which is the most widely used alternative medicine treatment, has been gradually recognized for its effectiveness; however, its mechanism of action is not fully understood. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is a thoroughly studied inflammasome that is closely associated with Alzheimer’s disease, spinal cord injury, and other diseases and plays an important role in the diagnosis and treatment of human immune system diseases. In recent years, some scholars have found that the NLRP3 inflammasome is a part of the mechanism of action of electroacupuncture, which has attracted further attention. In the current review, using “electroacupuncture” and “NLRP3 inflammasome” as keywords and based on the existing randomized controlled trials or clinical trials, we summarize the mechanisms of electroacupuncture targeting NLRP3 inflammasome in the treatment of different diseases and discuss how to optimize the electroacupuncture protocol to obtain thorough mechanisms of NLRP3 inflammasome in electroacupuncture and improve the level of evidence.

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