Microglia, the brain’s vigilant guardians, play a crucial role in maintaining stability and guarding against threats. Just like a clean-up crew, these cells are always on the lookout for any sign of trouble in the central nervous system (CNS). Recent research suggests that a process called autophagy, which helps microglia carry out their immune functions, is closely linked to brain health during both ischemic stroke (caused by blocked blood vessels) and hemorrhagic stroke (caused by bleeding in the brain). In this study, scientists explore how autophagy interacts with other biological processes in microglia under normal conditions and during disease. They also delve into the fascinating connection between microglial metabolism and autophagy. By understanding how microglial autophagy influences cerebrovascular diseases, we can gain valuable insights into potential therapeutic strategies to promote brain health.
Microglia are considered core regulators for monitoring homeostasis in the brain and primary responders to central nervous system (CNS) injuries. Autophagy affects the innate immune functions of microglia. Recently some evidence suggests that microglial autophagy is closely associated with brain function in both ischemic stroke and hemorrhagic stroke. Herein, we will discuss the interaction between autophagy and other biological processes in microglia under physiological and pathological conditions and highlight the interaction between microglial metabolism and autophagy. In the end, we focus on the effect of microglial autophagy in cerebrovascular diseases.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.