Just like how a regular workout routine keeps your body in tip-top shape, recent multi-omics studies have uncovered the incredible benefits of physical exercise on neurodegenerative diseases. Diseases like Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and Huntington’s are tough challenges for individuals and society as a whole. However, evidence suggests that exercise can bring about real improvements in the lives of those affected by these conditions. Think of it as a superhero swooping in to save the day! The studies analyzed a range of omics tools, including metabolomics, metagenomics, genomics, transcriptomics, and proteomics, to map the comprehensive biochemical changes that occur with exercise. Based on their findings, three main mechanisms emerged: adult neurogenesis, brain-derived neurotrophic factor (BDNF) signaling, and short-chain fatty acids (SCFAs) metabolism. These mechanisms may hold the key to understanding how exercise can prevent and alleviate the symptoms of neurodegenerative diseases. This research underscores the value of exercise as a complementary strategy alongside traditional treatments. Ongoing investigations should focus on uncovering more mechanisms behind exercise interventions and refining exercise programs for different neurodegenerative diseases. By diving deeper into this exciting field of study, we can discover new ways to combat these challenging conditions!
IntroductionNeurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease, are heavy burdens to global health and economic development worldwide. Mounting evidence suggests that exercise, a type of non-invasive intervention, has a positive impact on the life quality of elderly with neurodegenerative diseases. X-omics are powerful tools for mapping global biochemical changes in disease and treatment.MethodThree major databases were searched related to current studies in exercise intervention on neurodegenerative diseases using omics tools, including metabolomics, metagenomics, genomics, transcriptomics, and proteomics.ResultWe summarized the omics features and potential mechanisms associated with exercise and neurodegenerative diseases in the current studies. Three main mechanisms by which exercise affects neurodegenerative diseases were summed up, including adult neurogenesis, brain-derived neurotrophic factor (BDNF) signaling, and short-chain fatty acids (SCFAs) metabolism.ConclusionOverall, there is compelling evidence that exercise intervention is a feasible way of preventing the onset and alleviating the severity of neurodegenerative diseases. These studies highlight the importance of exercise as a complementary approach to the treatment and intervention of neurodegenerative diseases in addition to traditional treatments. More mechanisms on exercise interventions for neurodegenerative diseases, the specification of exercise prescriptions, and differentiated exercise programs should be explored so that they can actually be applied to the clinic.
Dr. David Lowemann, M.Sc, Ph.D., is a co-founder of the Institute for the Future of Human Potential, where he leads the charge in pioneering Self-Enhancement Science for the Success of Society. With a keen interest in exploring the untapped potential of the human mind, Dr. Lowemann has dedicated his career to pushing the boundaries of human capabilities and understanding.
Armed with a Master of Science degree and a Ph.D. in his field, Dr. Lowemann has consistently been at the forefront of research and innovation, delving into ways to optimize human performance, cognition, and overall well-being. His work at the Institute revolves around a profound commitment to harnessing cutting-edge science and technology to help individuals lead more fulfilling and intelligent lives.
Dr. Lowemann’s influence extends to the educational platform BetterSmarter.me, where he shares his insights, findings, and personal development strategies with a broader audience. His ongoing mission is shaping the way we perceive and leverage the vast capacities of the human mind, offering invaluable contributions to society’s overall success and collective well-being.