The Cognitive Journey in Parkinson’s Disease: Exploring the Transition from Aging to Dementia

Published on September 6, 2022

In the world of Parkinson’s disease, mild cognitive impairment (MCI) is like stepping stones on a path. It marks the transition stage between normal aging and full-blown dementia, and it serves as a powerful predictor of what lies ahead. While MCI has long been used to describe certain PD symptoms, consistent diagnostic criteria have been lacking. The reason? Cognitive functions vary greatly, each with its own progression. This review delves into the diagnostic criteria for PD-MCI, examining the heterogeneous nature of patients’ cognitive function, encompassing different types and progression rates. By shedding light on this topic, we pave the way for improved clinical diagnosis, early intervention, and treatment. But what unmet needs remain? And what does the future hold for this field? These questions are explored within this exciting article.

Mild cognitive impairment (MCI) is one of the common non-motor symptoms in patients with Parkinson’s disease (PD). MCI is the transition stage between normal aging and full-blown dementia and is also a powerful predictor of dementia. Although the concept of MCI has been used to describe some of the PD symptoms for many years, there is a lack of consistent diagnostic criteria. Moreover, because of the diverse patterns of the cognitive functions, each cognitive impairment will have a different progression. In this review, we overviewed the diagnostic criteria for PD-MCI, primarily focused on the heterogeneity of PD-MCI patients’ cognitive function, including various types of cognitive functions and their progression rates. A review of this topic is expected to be beneficial for clinical diagnosis, early intervention, and treatment. In addition, we also discussed the unmet needs and future vision in this field.

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