Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

Published on September 1, 2022

Just like a superhero coming to the rescue, pomegranate holds the potential to be a powerful ally in the fight against age-related neurological disorders (ANDs). Picture this: our brain, like an intricate puzzle, can sometimes fall apart as we age. ANDs, including well-known conditions like Alzheimer’s disease and Parkinson’s disease, are like the villainous misfits that cause this puzzle to crumble. But fear not! Pomegranate, with its rich concentration of polyphenols, arrives as our hero with its pharmacotherapeutic powers. It combats key enemies of ANDs like oxidative stress and inflammation while aiding in the clearance of misfolded proteins. By doing so, pomegranate could potentially halt or slow down the progression of these devastating disorders. With its versatility, pomegranate has long been used to heal various ailments, from diarrhea to respiratory diseases. But its promise in tackling ANDs is a relatively new revelation. To learn more about the exciting research surrounding the healing potentials of pomegranate in treating ANDs, dive into the comprehensive review article below!

Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer’s disease [AD] and Parkinson’s disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it. Pomegranate (Punica granatum L.) is one of the polyphenol-rich fruits that is widely mentioned in medical folklore. Pomegranate is commonly used to treat common disorders such as diarrhea, abdominal pain, wound healing, bleeding, dysentery, acidosis, microbial infections, infectious and noninfectious respiratory diseases, and neurological disorders. In the current review article, we aimed to summarize the data on the pharmacotherapeutic potentials of pomegranate in ANDs.

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