Cracking the Code of Cognitive Decline: EEG and Gait as Indicator Signals

Published on September 7, 2022

Imagine detective work, but instead of fingerprints and footprints, we’re using brain waves and walking patterns to uncover clues about cognitive impairment. In this study, scientists investigated whether a combination of electroencephalogram (EEG) and gait kinematic parameters could help identify individuals at risk of cognitive decline. They recruited 220 volunteers and collected data on their brain activity using a wireless EEG device and their walking patterns using motion capture equipment. The results showed that specific EEG patterns, like decreased activity in high beta and gamma bands, were associated with mild cognitive impairment (MCI). Additionally, certain gait parameters, such as pelvic obliquity angle, correlated with cognitive status. Combining these multimodal signals improved the ability to distinguish MCI individuals from healthy controls. These findings build upon previous research and provide new insights into the potential use of EEG and gait analysis as diagnostic tools for cognitive impairment. If you’re curious to learn more about this fascinating investigation, dig into the underlying research!

BackgroundEarly identification of people at risk for cognitive decline is an important step in delaying the occurrence of cognitive impairment. This study investigated whether multimodal signals assessed using electroencephalogram (EEG) and gait kinematic parameters could be used to identify individuals at risk of cognitive impairment.MethodsThe survey was conducted at the Veterans Medical Research Institute in the Veterans Health Service Medical Center. A total of 220 individuals volunteered for this study and provided informed consent at enrollment. A cap-type wireless EEG device was used for EEG recording, with a linked-ear references based on a standard international 10/20 system. Three-dimensional motion capture equipment was used to collect kinematic gait parameters. Mild cognitive impairment (MCI) was evaluated by Seoul Neuropsychological Screening Battery-Core (SNSB-C).ResultsThe mean age of the study participants was 73.5 years, and 54.7% were male. We found that specific EEG and gait parameters were significantly associated with cognitive status. Individuals with decreases in high-frequency EEG activity in high beta (25–30 Hz) and gamma (30–40 Hz) bands increased the odds ratio of MCI. There was an association between the pelvic obliquity angle and cognitive status, assessed by MCI or SNSB-C scores. Results from the ROC analysis revealed that multimodal signals combining high beta or gamma and pelvic obliquity improved the ability to discriminate MCI individuals from normal controls.ConclusionThese findings support prior work on the association between cognitive status and EEG or gait, and offer new insights into the applicability of multimodal signals to distinguish cognitive impairment.

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