Just like detectives investigating a mysterious crime, scientists sought to unravel the connection between Alzheimer’s disease and oral frailty by studying mice. In this case, they honed in on the mesencephalic trigeminal nucleus (Vmes), which controls chewing. By using immunohistochemistry, they discovered that 3 × Tg-AD mice, a model of AD, exhibited amyloid-β deposition and […]
Imagine you’re making a batch of cookies, and you need a specific ingredient called spermidine. This ingredient has been shown to affect how well the cookies turn out, but you’re not exactly sure how much you should use. Well, scientists have been studying the effects of spermidine on cognitive function in humans, and their findings […]
Imagine the brain as a web of connections, where different regions communicate to perform various tasks. In Parkinson’s disease (PD), the cerebellum, particularly the cerebellar dentate nucleus (DN), is implicated in causing involuntary muscle movements known as peak-dose dyskinesia. However, the exact neural mechanism behind this remains unclear. To shed light on this phenomenon, researchers […]
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