Monocyte and Lipoprotein Ratio Linked to Hemorrhagic Stroke Risk

Published on August 16, 2022

Imagine your bloodstream is a busy city, with different cells constantly moving around. In the case of acute ischemic stroke patients on intravenous thrombolysis, there is a potential danger looming: hemorrhagic transformation (HT). Researchers investigated the connection between HT risk and the ratio of monocyte count to high-density lipoprotein level (MHR). They found that patients with a higher MHR were more likely to suffer from HT. In fact, patients with an MHR falling in the third and fourth quartiles faced significantly higher risks. This study suggests that a high MHR may independently increase the chance of HT in stroke patients undergoing intravenous thrombolysis. To fully understand this link, it’s important to dive into the research and explore the complex biology behind monocytes, lipoproteins, and hemorrhagic strokes.

BackgroundHemorrhagic transformation (HT) is a frequent, serious complication in acute ischemic stroke patients on intravenous thrombolysis. Here we investigated whether risk of HT is associated with the ratio of monocyte count to high-density lipoprotein level (MHR).Materials and methodsMedical records were retrospectively examined for consecutive patients with acute ischemic stroke who received thrombolytic therapy. HT was diagnosed by computed tomography at 24–36 h after therapy. Potential association between MHR and HT was examined using logistic regression.ResultsA total of 340 patients were analyzed, and their median MHR was 0.44 (0.31–0.59). MHR was higher in the 51 patients (15.0%) with HT than in those who did not suffer HT (0.53 vs. 0.42, P = 0.001). Multivariate logistic regression showed that, after adjusting for potential confounders, MHR was an independent risk factor for HT (OR 7.50, 95% CI 1.64 to 34.35, P = 0.009). Risk of HT was significantly higher among patients whose MHR fell in the third quartile (0.42–0.53) and the fourth quartile (> 0.53) than among those with MHR in the first quartile (< 0.31; OR 3.53, 95% CI 1.11 to 11.20, P = 0.032; OR 4.79, 95% CI 1.49 to 15.42, P = 0.009).ConclusionHigh MHR may be independently associated with higher risk of HT in patients with acute ischemic stroke on intravenous thrombolysis.

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